These software solutions have been in active use for some time for the well‐established population PK approaches. To illustrate the scale of this issue, it should be noted that PBPK projects not uncommonly rely on extracted data gathered from up to 50 articles.įortunately, several off‐the‐shelf digitization software packages that allow the extraction of numerical information from their two‐dimensional graphical representation are currently available.
Despite the potential to automatically data‐mine population average pharmacokinetic (PK) data for certain applications,ĭata extraction from graphical representations still requires manual efforts. As a result, researchers must extract the information of interest from the graphical representation to use the data for their modeling approaches.
Unfortunately, published data are typically presented in aggregate form as plots or graphs without providing access to the underlying raw, uncondensed data. However, for model development, time-dependent data of pharmacological relevant processes are a crucial requirement. However, because the greatest pitfall comes from pre-existing errors, we recommend always making published data available as raw values.ĭuring the past few years, quantitative systems pharmacology (QSP) and especially physiologically-based pharmacokinetics modeling (PBPK) have proven to be an important cornerstone of model-informed drug discovery and development. Our findings suggest that data digitizing is precise and important. Analysis of 181 literature peak plasma concentration values revealed a considerable discrepancy between reported and post hoc digitized data with 85% having ζ > 5%. Although significant, no relevant confounders were found (mean ζ ± SD circles = 0.69% ± 0.68% vs. Accuracy, precision, confounder influence, and variability were investigated using scaled median symmetric accuracy (ζ), thus finding excellent accuracy (mean ζ = 0.99%). To quantify their relevance, a literature search revealed a remarkable mean increase of 16% per year in publications citing digitizing software together with QSP or PBPK. We answer your questions within 24-48 hours (Weekend off).Ĭhannel: If you want the latest software updates and discussion about any software in your pocket, then here is our Telegram channel.In quantitative systems pharmacology (QSP) and physiologically‐based pharmacokinetic (PBPK) modeling, data digitizing is a valuable tool to extract numerical information from published data presented as graphs. You may also use our social and accounts by following Whatsapp, Facebook, and Twitter for your questions. Our Contact: Kindly use our contact page regards any help. Want to add more GraphClick alternatives: If anyone wants to add the more GraphClick alternative to this list, then contact us or use the review section below. Misinformation: If you want to correct any misinformation about GraphClick and similar Software listed on this page, then kindly contact us. If you have any queries regards the GraphClick software and GraphClick alternatives software, then please ask us through the comment and review section below. You may visit the developer profile by following the link.įor our visitors: If you are interested in rating the GraphClick alternatives and similar Software, then please use our rating review section to review this item. The developer of the GraphClick software we mentioned above in the description section.
Take a graph or data from any source (eg a web or PDF document), add your comments and make any manipulations such as nonlinear regression or curve fit….Ĭharts are great for understanding results in reports and papers, but to use those results in your own analysis, you want the underlying numeric data.
Want to see more alternatives for GraphClick? Search Graph With fast and efficient image processing behind the scenes … Im2graph is a free digitizing software that converts chart images into chart data, that is, into numbers. Software tool written in Java for digitizing data from an image of a graph or plot.ĭigitization software automatically converts graphic image files into usable (x, y) data. Sometimes it is necessary to extract data values from graphs, for example in most scientific publications only plots but no data values are published. g3data makes the extraction process much … Digitize it Publications often include graphs, but the actual data is missing. G3data is used for extracting data from graphs. Often data is displayed in reports and references as functional XY type … Plot Digitizer is a Java program used to digitize scanned plots with functional data.